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ML324

Chemical Structure : ML324

CAS No.: 1222800-79-4

ML324 (ML-324)

Catalog No.: PC-43163Not For Human Use, Lab Use Only.

ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity).
ML324 causes depression-like phenotype even in absence of stress exposure, which is associated with an increase in transcriptionally repressive epigenetic marks H3K9me2/me3 in nucleus accumbens (NAc).
ML324 blocks TNF-α-mediated neutrophil adhesion, reduces TNF-α-induced ICAM1 protein expression in cerebral microvessels.

Physicochemical Properties

M.Wt 349.4262
Formula C21H23N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

Benzamide, N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-

References

1. Rai G, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Pathak SS, et al. Neuropsychopharmacology. 2017 Mar;42(4):854-863.

3. Choi JY, et al. Sci Rep. 2017 Mar 22;7:45005.

4. Ishiguro K, et al. Clin Immunol. 2017 Jul;180:120-127.

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