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Chemical Structure : ML324
CAS No.: 1222800-79-4
Catalog No.: PC-43163Not For Human Use, Lab Use Only.
ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $368 | In stock | |
| 250 mg | $658 | In stock | |
| 1 g | Get quote |
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ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity).
ML324 causes depression-like phenotype even in absence of stress exposure, which is associated with an increase in transcriptionally repressive epigenetic marks H3K9me2/me3 in nucleus accumbens (NAc).
ML324 blocks TNF-α-mediated neutrophil adhesion, reduces TNF-α-induced ICAM1 protein expression in cerebral microvessels.
| M.Wt | 349.4262 | |
| Formula | C21H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)- |
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1. Rai G, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Pathak SS, et al. Neuropsychopharmacology. 2017 Mar;42(4):854-863.
3. Choi JY, et al. Sci Rep. 2017 Mar 22;7:45005.
4. Ishiguro K, et al. Clin Immunol. 2017 Jul;180:120-127.
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