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ML334

Chemical Structure : ML334

CAS No.: 1432500-66-7

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ML334 (LH601A, (SRS)-5)

Catalog No.: PC-22765Not For Human Use, Lab Use Only.

ML334 (LH601A) is a cell permeable inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction (PPI) with ARE-inducing EC50 of 18 uM, promotes the nuclear translocation of Nrf2 with EC50 of 12 uM in Keap1-Nrf2 functional assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML334 (LH601A) is a cell permeable inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction (PPI) with ARE-inducing EC50 of 18 uM, promotes the nuclear translocation of Nrf2 with EC50 of 12 uM in Keap1-Nrf2 functional assay.
ML334 binds to Keap1 Kelch domain, inhibits the Keap1-Nrf2 protein-protein interaction by non-covalent binding.

Physicochemical Properties

M.Wt 446.50
Formula C26H26N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid

References

1. Hu L, et al. Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43.

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