ML354 |CAS:89159-60-4 Probechem Biochemicals

Chemical Structure : ML354

ML354 (VU0099704)

Catalog No.: PC-62125Not For Human Use, Lab Use Only.

ML354 (VU0099704) is a novel potent and selective PAR4 antagonist with IC50 of 140 nM, displays 71-fold selectivity versus PAR-1.

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Biological Activity

ML354 (VU0099704) is a novel potent and selective PAR4 antagonist with IC50 of 140 nM, displays 71-fold selectivity versus PAR-1。
ML354 (VU0099704) also displays improved physical properties and is very amenable to future medicinal chemistry development.

Physicochemical Properties

M.Wt	282.29
Formula	C16H14N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-5-nitro-3-phenyl-1H-indole-2-methanol

References

1. Wen W, et al. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4708-13.

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ML354 (VU0099704)

Biological Activity

Physicochemical Properties

References

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