ML368 (SR9186)

Chemical Structure : ML368

Catalog No.: PC-62112Not For Human Use, Lab Use Only.

ML368 (SR9186) is a potent, selective cytochrome P450 enzyme CYP3A4 inhibitor with IC50 of 4 nM (convert testosterone to hydroxytestosterone), displays >2,000-fold selectivity over CYP3A5.

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Biological Activity

ML368 (SR9186) is a potent, selective cytochrome P450 enzyme CYP3A4 inhibitor with IC50 of 4 nM (convert testosterone to hydroxytestosterone), displays >2,000-fold selectivity over CYP3A5.

Physicochemical Properties

M.Wt	430.5
Formula	C26H18N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4'-cyano[1,1'-biphenyl]-4-yl)-N'-[4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl]-urea

References

1. Li X, et al. Drug Metab Dispos. 2012 Sep;40(9):1803-9.

2. Towles JK, et al. Drug Metab Dispos. 2016 Oct;44(10):1584-97.

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ML368 (SR9186)

Biological Activity

Physicochemical Properties

References

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