ML379 |CAS:1630760-58-5 Probechem Biochemicals

Chemical Structure : ML379

ML379 (CID71576758)

Catalog No.: PC-62117Not For Human Use, Lab Use Only.

ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant).

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Biological Activity

ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant).
ML379 displays >1,000-fold selectivity over insensitive A549 cells (TP53 wild type).
ML379 displays low nM activity in a larger panel of TP53 mutant cell lines.

Physicochemical Properties

M.Wt	273.33
Formula	C15H19N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-Methyl-6-(4-morpholinophenyl)-4,5-dihydropyridazin-3(2H)-one

References

1. Lewis TA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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ML379 (CID71576758)

Biological Activity

Physicochemical Properties

References

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