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Chemical Structure : ML390
CAS No.: 2029049-79-2
Catalog No.: PC-42227Not For Human Use, Lab Use Only.
ML390 is a potent DHODH inhibitor that causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) AML models (ED50=2 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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ML390 is a potent DHODH inhibitor that causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) AML models (ED50=2 uM).
ML390 but shows low solubility and bioavailability, the relative compound BRQ can be used in vivo.
| M.Wt | 406.3983 | |
| Formula | C21H21F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL |
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| Chemical Name/SMILES |
(R)-N-(3-oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide |
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1. Sykes DB, et al. Cell. 2016 Sep 22;167(1):171-186.e15.
2. Lewis TA, et al. ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117.
3. Sykes DB, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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