ML398 |CAS:1620203-88-4 Probechem Biochemicals

Chemical Structure : ML398

ML398 (CID72737723, ML 398)

Catalog No.: PC-62128Not For Human Use, Lab Use Only.

ML398 (CID72737723) is a potent, selective, highly brain penetrant dopamine 4 (D4R) receptor antagonist with IC50/Ki of 130 nM/60 nM.

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Biological Activity

ML398 (CID72737723) is a potent, selective, highly brain penetrant dopamine 4 (D4R) receptor antagonist with IC50/Ki of 130 nM/60 nM.
ML398 (CID72737723) shows excellent selectivity (>100-fold) against the other dopamine receptor subtypes (D1,2S,2L,3,5; >20 uM).
ML398 (CID72737723) reverses cocaine-induced hyperlocomotion at 10 mg/kg in vivo.

Physicochemical Properties

M.Wt	315.841
Formula	C19H22ClNO
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(4-chlorobenzyl)-2-phenethylmorpholine

References

1. Berry CB, et al. ACS Med Chem Lett. 2014 Jul 9;5(9):1060-4.

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ML398 (CID72737723, ML 398)

Biological Activity

Physicochemical Properties

References

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