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Chemical Structure : ML417
CAS No.: 1386162-69-1
Catalog No.: PC-72158Not For Human Use, Lab Use Only.
ML417 (ML 417) is a novel potent and uniquely selective D3 dopamine receptor (D3R) full agonist with EC50 of 38 nM in β-arrestin recruitment assays.
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| 100 mg | $498 | In stock | |
| 250 mg | $798 | In stock | |
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ML417 (ML 417) is a novel potent and uniquely selective D3 dopamine receptor (D3R) full agonist with EC50 of 38 nM in β-arrestin recruitment assays. ML417 displays global selectivity at all other receptor subtypes, very limited activity (IC50 > 50 uM) at all subtypes except for the D2R, exhibits submicromolar affinity for only 3 targets, the β1-adrenergic, 5-HT2B, and σ-1 receptor in large arrays of GPCRs and several transporters or ion channels.
ML417 potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors.
ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA-induced cell death.
| M.Wt | 379.46 | |
| Formula | C22H25N3O3 | |
| Appearance | Solid | |
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1. J Med Chem. 2020 May 28;63(10):5526-5567.
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