Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ML417
CAS No.: 1386162-69-1
Catalog No.: PC-72158Not For Human Use, Lab Use Only.
ML417 (ML 417) is a novel potent and uniquely selective D3 dopamine receptor (D3R) full agonist with EC50 of 38 nM in β-arrestin recruitment assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ML417 (ML 417) is a novel potent and uniquely selective D3 dopamine receptor (D3R) full agonist with EC50 of 38 nM in β-arrestin recruitment assays. ML417 displays global selectivity at all other receptor subtypes, very limited activity (IC50 > 50 uM) at all subtypes except for the D2R, exhibits submicromolar affinity for only 3 targets, the β1-adrenergic, 5-HT2B, and σ-1 receptor in large arrays of GPCRs and several transporters or ion channels.
ML417 potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors.
ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA-induced cell death.
| M.Wt | 379.46 | |
| Formula | C22H25N3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(1H-indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone |
|
1. Moritz AE, et al. J Med Chem. 2020 May 28;63(10):5526-5567.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
