Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-ML 604086
ML 604086

Chemical Structure : ML 604086

CAS No.: 850330-18-6

ML 604086 (ML604086)

Catalog No.: PC-61979Not For Human Use, Lab Use Only.

ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3 uM and 1.0 uM respectively in cellular assays.

Packing Price Stock Quantity
10 mg $198 In stock
25 mg $348 In stock
50 mg $598 In stock
100 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: 98.67% (LCMS) Select Batch:

Biological Activity

ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3 uM and 1.0 uM respectively in cellular assays.
ML 604086 displays high selectvity against a panel of 40 GPCRs, only moderately inhibits 5HT1a (30% at 10 uM).

Physicochemical Properties

M.Wt 508.637
Formula C27H32N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[4-[[[(3R,4R)-1-[(2S)-2-Amino-1-oxopropyl]-3-methyl-4-piperidinyl]amino]sulfonyl]-1-naphthalenyl]-2-methylbenzamide

References

1. Jenkins TJ, et al. J Med Chem. 2007 Feb 8;50(3):566-84.

2. Wang L, et al. Thorax. 2013 Jun;68(6):506-12.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: