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ML 604086

Chemical Structure : ML 604086

CAS No.: 850330-18-6

ML 604086 (ML604086)

Catalog No.: PC-61979Not For Human Use, Lab Use Only.

ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3 uM and 1.0 uM respectively in cellular assays.

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Purity & Documentation Purity: 98.67% (LCMS) Select Batch:

Biological Activity

ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3 uM and 1.0 uM respectively in cellular assays.
ML 604086 displays high selectvity against a panel of 40 GPCRs, only moderately inhibits 5HT1a (30% at 10 uM).

Physicochemical Properties

M.Wt 508.637
Formula C27H32N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[4-[[[(3R,4R)-1-[(2S)-2-Amino-1-oxopropyl]-3-methyl-4-piperidinyl]amino]sulfonyl]-1-naphthalenyl]-2-methylbenzamide

References

1. Jenkins TJ, et al. J Med Chem. 2007 Feb 8;50(3):566-84.

2. Wang L, et al. Thorax. 2013 Jun;68(6):506-12.

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