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Chemical Structure : MLN8054
CAS No.: 869363-13-3
Catalog No.: PC-42424Not For Human Use, Lab Use Only.
MLN8054 is a potent, selective, ATP-competitive, orally active Aurora A kinase inhibitor with IC50 of 4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $48 | In stock | |
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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MLN8054 is a potent, selective, ATP-competitive, orally active Aurora A kinase inhibitor with IC50 of 4 nM.
MLN8054 displays >40-fold selectivity over Aurora B, and >100-fold selectivity over a panel of kinases.
MLN8054 causes G(2)/M accumulation and spindle defects and inhibits proliferation in multiple cultured human tumor cells lines.
MLN8054 dramatically inhibits the growth of human tumor xenografts in nude mice.
| M.Wt | 476.862 | |
| Formula | C25H15ClF2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]- |
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1. Manfredi MG, et al. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4106-11.
2. Hoar K, et al. Mol Cell Biol. 2007 Jun;27(12):4513-25.
3. Dar AA, et al. Cancer Res. 2008 Nov 1;68(21):8998-9004.
4. Macarulla T, et al. Mol Cancer Ther. 2010 Oct;9(10):2844-52.
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