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MLS-0437605

Chemical Structure : MLS-0437605

CAS No.: 862975-18-6

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MLS-0437605 (MLS0437605)

Catalog No.: PC-35138Not For Human Use, Lab Use Only.

MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MLS-0437605 is a specific inhibitor of dual-specificity phosphatase 3 (DUSP3) with IC50 of 3.7 uM, 7-fold selectivity over USP22 and >4-fold selectivity over other 10 PTPs (HePTP, TCPTP, PTP1B, etc.).
    MLS-0437605 specifically inhibits collagen- and C-type lectin-like receptor 2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells.

    Physicochemical Properties

    M.Wt 342.348
    Formula C16H11FN4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-fluorobenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine

    References

    1. Musumeci L, et al. Circulation. 2015 Feb 17;131(7):656-68.

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