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MMG-11

Chemical Structure : MMG-11

CAS No.: 313254-94-3

MMG-11 (MMG11)

Catalog No.: PC-38134Not For Human Use, Lab Use Only.

MMG-11 (MMG11) is a potent and selective TLR2 antagonist with pA2 values of 5.73 and 6.15 (TLR2/1), preferentially inhibits TLR2/1 signaling.

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Biological Activity

MMG-11 (MMG11) is a potent and selective TLR2 antagonist with pA2 values of 5.73 and 6.15 (TLR2/1), preferentially inhibits TLR2/1 signaling.
MMG-11 preferentially inhibited TLR2/1 signaling in promoter cells stably expressing TLR2 heterodimers and mouse macrophages.
MMG-11 blocked ligand-induced interaction of TLR2 with MyD88 and reduced MAP kinase and NF-κB activation.

Physicochemical Properties

M.Wt 306.27
Formula C15H14O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 1 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate

References

1. Grabowski M, et al. Biochem Pharmacol. 2018 Aug;154:148-160. 

2. Grabowski M, et al. Biochem Pharmacol. 2020 Jan;171:113687.

3. Bermudez M, et al. ChemMedChem. 2020 Jul 20;15(14):1364-1371.

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