Catalog No.: PC-21376Not For Human Use, Lab Use Only.
MMT3-72 is a gastrointestinal locally-activating Janus kinase (JAK) inhibitor, readily converted to MMT3-72-M2 in the colon contents (JAK1 IC50=10.8 nM, JAK2 IC50=26.3 nM and TYK2 IC50=91.6 nM).
MMT3-72 is a gastrointestinal locally-activating Janus kinase (JAK) inhibitor, readily converted to MMT3-72-M2 in the colon contents (JAK1 IC50=10.8 nM, JAK2 IC50=26.3 nM and TYK2 IC50=91.6 nM).
MMT3-72 is inactive but MMT3-72-M2 is more potent against JAK1, 2, and TYK2 by in vitro kinase assays.
MMT3-72 locally activated in the GI tract to release active metabolite MMT3-72-M2 which achieved high exposure in the GI tissues and minimized exposure in the plasma.
MMT3-72 exhibited superior efficacy in treating UC in mice compared with tofacitinib.
