MMV006833 | PfSTART1 inhibitor | Probechem Biochemicals

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Chemical Structure : MMV006833

MMV006833 (M-833)

Catalog No.: PC-22542Not For Human Use, Lab Use Only.

MMV006833 (M-833) is a small molecule inhibitor of PfSTART1 with EC50 of 1.1 uM for Pf 3D7, binds to PfSTART1(WT) with KD of 42 nM, inhibits ring-stage development of Plasmodium falciparum, prevents PfSTART1 from expanding the vacuole membrane encasing the parasite after red blood cell invasion, thereby blocking parasite growth.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	414.95
Formula	C19H27ClN2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-chloro-2-methyl-5-(pyrrolidin-1-ylsulfonyl)phenoxy)-N-cyclohexylacetamide

References

1. Madeline G Dans, et al. Nat Commun. 2024 Jun 18;15(1):5219.

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MMV006833 (M-833)

Biological Activity

Physicochemical Properties

References

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