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MMV006833

Chemical Structure : MMV006833

CAS No.: 701253-55-6

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MMV006833 (M-833)

Catalog No.: PC-22542Not For Human Use, Lab Use Only.

MMV006833 (M-833) is a small molecule inhibitor of PfSTART1 with EC50 of 1.1 uM for Pf 3D7, binds to PfSTART1(WT) with KD of 42 nM, inhibits ring-stage development of Plasmodium falciparum, prevents PfSTART1 from expanding the vacuole membrane encasing the parasite after red blood cell invasion, thereby blocking parasite growth.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MMV006833 (M-833) is a small molecule inhibitor of PfSTART1 with EC50 of 1.1 uM for Pf 3D7, binds to PfSTART1(WT) with KD of 42 nM, inhibits ring-stage development of Plasmodium falciparum, prevents PfSTART1 from expanding the vacuole membrane encasing the parasite after red blood cell invasion, thereby blocking parasite growth.

Physicochemical Properties

M.Wt 414.95
Formula C19H27ClN2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-chloro-2-methyl-5-(pyrrolidin-1-ylsulfonyl)phenoxy)-N-cyclohexylacetamide

References

1. Madeline G Dans, et al. Nat Commun. 2024 Jun 18;15(1):5219.

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