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Chemical Structure : MMV1557817
Catalog No.: PC-22373Not For Human Use, Lab Use Only.
MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 (Ki=308/19 nM) and M17 (Ki=112/208 nM), demonstrates potent activity against asexual and sexual stage parasites.
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MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 (Ki=308/19 nM) and M17 (Ki=112/208 nM), demonstrates potent activity against asexual and sexual stage parasites.
MMV1557817 exhibits potent activity against P. falciparum asexual Pf3D7 with EC50 of 39 nM, kills the sexual stages of early (stages I–III), late (stages IV–V) and mature (stage V) gametocytes with IC50 of 99 nM, 309 nM, and 1474 nM, respectively.
MMV1557817 retains nanomolar range activity against drug-resistant and clinical isolates of P. falciparum and P. vivax.
MMV1557817 shows good selectivity, safety, ADME, and exposure properties and is active in vivo against the rodent malaria species Plasmodium berghei.
| M.Wt | 394.39 | |
| Formula | C20H21F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Edgar RCS, et al. mBio. 2024 May 8:e0096624.
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