Chemical Structure : MMV1581361
CAS No.:
MMV1581361
Catalog No.: PC-26055Not For Human Use, Lab Use Only.
MMV1581361 is a potent inhibitor of Plasmodium falciparum ATP4 (PfATP4), inhibits 3D7 P. falciparum Strain with IC50 of 0.03 uM, disrupts Na+ ion homeostasis in P. falciparum.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MMV1581361 is a potent inhibitor of Plasmodium falciparum ATP4 (PfATP4), inhibits 3D7 P. falciparum Strain with IC50 of 0.03 uM, disrupts Na+ ion homeostasis in P. falciparum.
MMV1581361 shows high potency against 56 fresh Plasmodium falciparum field parasites collected from patients in the Tororo District, Uganda, with mean IC50 of 41 nM.
MMV1581361 (25 mg/kg) displays a moderate rate-of-kill profile similar to pyrimethamine in vitro and efficacy in the humanized P. falciparum Pf3D70087/N9 NODscidIL2Rγnull mouse model.
MMV1581361 demonstrates significant transmission-blocking potential, achieving 90% inhibition of male gamete exflagellation, a 98% reduction in mean oocyst intensity, and an 88% block in transmission
Physicochemical Properties
|
M.Wt
|
434.45
|
|
Formula
|
C16H17F3N4O3S2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-Methyl-4-((4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)sulfonyl)thiophene-2-carboxamide
|
References
1. Onyame HA, et al. J Med Chem. 2026 Feb 11. doi: 10.1021/acs.jmedchem.5c01954.
Contact Us
sales@probechem.com
