Chemical Structure : MMV665917
CAS No.:
904576-65-4
MMV665917
(MMV-665917)
Catalog No.: PC-26851Not For Human Use, Lab Use Only.
MMV665917 is an orally active piperazine-based compound with high selectivity for the blood stages of malaria parasites and for Cryptosporidium species (Cryptosporidium parvum, EC90=15 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MMV665917 is an orally active piperazine-based compound with high selectivity for the blood stages of malaria parasites and for Cryptosporidium species (Cryptosporidium parvum, EC90=15 uM).
MMV665917 shows roughly equivalent potency for multiple C. parvum lab and field isolates, and for the C. hominis TU502 isolate.
MMV665917 reduces parasite shedding to below detectable limits in a highly immunocompromised mouse model of chronic C. parvum infection.
Physicochemical Properties
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M.Wt
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357.80
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Formula
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C16H16ClN7O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-Piperazinecarboxamide, N-(4-chlorophenyl)-4-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)-
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References
1. Stebbins E, et al. PLoS Negl Trop Dis. 2018 Jan 8;12(1):e0006183.
2. Jumani RS, et al. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01505-17.
3. Oboh E, et al. J Med Chem. 2021 Aug 12;64(15):11729-11745.
4. Lee S, et al. J Infect Dis. 2019 Jun 19;220(2):285-293.
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