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Chemical Structure : MN58b
CAS No.: 203192-01-2
Catalog No.: PC-60866Not For Human Use, Lab Use Only.
MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $198 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism.
MN58b demonstrates antiproliferative properties against human tumor-derived cell lines (HT29 IC50=0.5 uM) and antitumor activity against human tumor xenografts in vivo.
| M.Wt | 640.508 | |
| Formula | C32H40Br2N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,1'-((butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide |
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1. Lacal JC, et al. Mol Cancer Ther. 2015 Jan;14(1):31-9.
2. Hernández-Alcoceba R, et al. Cancer Res. 1999 Jul 1;59(13):3112-8.
3. Al-Saffar NM, et al. Cancer Res. 2006 Jan 1;66(1):427-34.
4. Guma M, et al. Ann Rheum Dis. 2015 Jul;74(7):1399-407.
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