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Chemical Structure : MO-2097
Catalog No.: PC-21420Not For Human Use, Lab Use Only.
MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia.
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MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia.
MO-2097 inhibits HIF-1α protein translation and reduces its target gene transcriptional activity, leading to the accumulation of mitochondrial ROS and reduced glucose metabolism.
MO-2097 (25 mg/kg and 50 mg/kg) is a potent inducer of tumor cell apoptosis in the HeLa CCL2 cells xenograft assay, inhibits HIF-1α protein expression and tumor apoptosis in vivo.
MO-2097 attenuates tumor growth in vivo in xenograft HCT116 cell mouse model and colon cancer patient-derived organoids.
| M.Wt | 308.33 | |
| Formula | C19H16O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Han HJ, et al. J Adv Res. 2023 Nov 15:S2090-1232(23)00353-3.
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