Chemical Structure : MO-2097
CAS No.:
2744300-63-6
MO-2097
(MO 2097)
Catalog No.: PC-21420Not For Human Use, Lab Use Only.
MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia.
MO-2097 inhibits HIF-1α protein translation and reduces its target gene transcriptional activity, leading to the accumulation of mitochondrial ROS and reduced glucose metabolism.
MO-2097 (25 mg/kg and 50 mg/kg) is a potent inducer of tumor cell apoptosis in the HeLa CCL2 cells xenograft assay, inhibits HIF-1α protein expression and tumor apoptosis in vivo.
MO-2097 attenuates tumor growth in vivo in xenograft HCT116 cell mouse model and colon cancer patient-derived organoids.
Physicochemical Properties
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M.Wt
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308.33
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Formula
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C19H16O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(7-methyl-5,8-dihydrooxepino[3,2-f]benzofuran-2-yl)benzene-1,3-diol
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References
1. Han HJ, et al. J Adv Res. 2023 Nov 15:S2090-1232(23)00353-3.
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