Chemical Structure : MO-I-1100
CAS No.:
1585217-40-8
MO-I-1100
Catalog No.: PC-49471Not For Human Use, Lab Use Only.
MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells.
MO-I-1100 (1 uM) inhibited cell viability of FOCUS cells, which have high level ASPH expression, but had no effect on NIH3T3 cells which lacked ASPH on the cell surface.
MO-I-1100 reduced cell motility and invasiveness in human and murine HCC cell lines, MO-I-1100 (5 uM) reduced expression of Notch responsive genes (HES1 and HEY1).
MO-I-1100 (50 mg/kg) reduces tumor growth in an intrahepatic orthotopic xenograft model of HCC, with significantly reduced levels of activated Notch 1, HES1 and HEY1.
Physicochemical Properties
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M.Wt
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379.811
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Formula
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C17H14ClNO5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-amino-5-(4-chlorophenyl)-4-oxo-4,5-dihydrofuran-3-yl phenylmethanesulfonate
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References
1. Aihara A, et al. Hepatology. 2014 Oct;60(4):1302-13.
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