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MO-I-1100

Chemical Structure : MO-I-1100

CAS No.: 1585217-40-8

MO-I-1100

Catalog No.: PC-49471Not For Human Use, Lab Use Only.

MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells.
MO-I-1100 (1 uM) inhibited cell viability of FOCUS cells, which have high level ASPH expression, but had no effect on NIH3T3 cells which lacked ASPH on the cell surface.
MO-I-1100 reduced cell motility and invasiveness in human and murine HCC cell lines, MO-I-1100 (5 uM) reduced expression of Notch responsive genes (HES1 and HEY1).
MO-I-1100 (50 mg/kg) reduces tumor growth in an intrahepatic orthotopic xenograft model of HCC, with significantly reduced levels of activated Notch 1, HES1 and HEY1.

Physicochemical Properties

M.Wt 379.811
Formula C17H14ClNO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-amino-5-(4-chlorophenyl)-4-oxo-4,5-dihydrofuran-3-yl phenylmethanesulfonate

References

1. Aihara A, et al. Hepatology. 2014 Oct;60(4):1302-13.

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