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MPC-0767

Chemical Structure : MPC-0767

CAS No.: 1310540-32-9

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MPC-0767 (MPC 0767;MPC0767;MPC3100 mesylate hydrate)

Catalog No.: PC-60470Not For Human Use, Lab Use Only.

MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100, which is a potent, selective, orally bioavailable Hsp90 inhibitor with IC50 of 0.14 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100, which is a potent, selective, orally bioavailable Hsp90 inhibitor with IC50 of 0.14 uM.
    MPC-0767 exhibits improved aqueous solubility, adequate chemical stability, and rapid bioconversion without the need for solubilizing excipients.

    Physicochemical Properties

    M.Wt 663.559
    Formula C23H31BrN6O8S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S)-1-[4-[2-[6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9H-purin-9-yl]ethyl]-1-piperidinyl]-2-hydroxy-1-propanone mesylate hydrate

    References

    1. Kim SH, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5254-7.

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