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MPI5

Chemical Structure : MPI5

CAS No.: 2481133-56-4

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MPI5 (MPro inhibitor MPI5)

Catalog No.: PC-72436Not For Human Use, Lab Use Only.

MPI8 is a highly potent SARS-CoV-2 main protease (MPro) inhibitor with IC50 of 33 nM, completely prevented the SARS-CoV-2-induced cytopathogenic effect in Vero E6 cells at 2.5-5 uM and A549 cells at 0.16-0.31 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MPI8 is a highly potent SARS-CoV-2 main protease (MPro) inhibitor with IC50 of 33 nM, completely prevented the SARS-CoV-2-induced cytopathogenic effect in Vero E6 cells at 2.5-5 uM and A549 cells at 0.16-0.31 uM.

    Physicochemical Properties

    M.Wt 542.677
    Formula C29H42N4O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    benzyl ((S)-1-(((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

    References

    1. Ma XR, et al. ChemMedChem. 2022 Jan 5;17(1):e202100456.

    2. Yang KS, et al. bioRxiv. 2020 Jul 28:2020.07.28.223784.

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