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MPT0E028

Chemical Structure : MPT0E028

CAS No.: 1338320-94-7

MPT0E028 (MPT0 E028)

Catalog No.: PC-35302Not For Human Use, Lab Use Only.

MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells, 9-30 times more potent than SAHA.

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Biological Activity

MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells, 9-30 times more potent than SAHA.
MPT0E028 inhibits class I HDAC1, HDAC2, and class Iib HDAC6 with IC50 of 53, 106, and 29.5 nM, respectively, weakly inhibits HDAC8 (IC50=2.5 uM), but not for HDAC4 (IC50>10 uM).
MPT0E028 inhibits the growth of HCT116 and MDA-MB-231 cells with IC50 of 0.09 and 0.19 uM.
MPT0E028 inhibits HCT116 tumor xenograft in vivo without significant adverse effects, shows stronger anti-cancer efficacy than SAHA.

Physicochemical Properties

M.Wt 344.385
Formula C17H16N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-N-hydroxy-3-(1-(phenylsulfonyl)indolin-5-yl)acrylamide

References

1. Huang HL, et al. PLoS One. 2012;7(8):e43645.

2. Chen MC, et al. Cell Death Dis. 2013 Sep 19;4:e810.

3. Chen CH, et al. Clin Cancer Res. 2014 Mar 1;20(5):1274-1287.

4. Huang HL, et al. Oncotarget. 2015 Mar 10;6(7):4976-91.

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