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Chemical Structure : MPT0E028
CAS No.: 1338320-94-7
Catalog No.: PC-35302Not For Human Use, Lab Use Only.
MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells, 9-30 times more potent than SAHA.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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MPT0E028 (MPT 0E028) is a potent HDAC inhibitor that inhibits nuclear HDAC activity with IC50 of 11.1 nM in HeLa cells, 9-30 times more potent than SAHA.
MPT0E028 inhibits class I HDAC1, HDAC2, and class Iib HDAC6 with IC50 of 53, 106, and 29.5 nM, respectively, weakly inhibits HDAC8 (IC50=2.5 uM), but not for HDAC4 (IC50>10 uM).
MPT0E028 inhibits the growth of HCT116 and MDA-MB-231 cells with IC50 of 0.09 and 0.19 uM.
MPT0E028 inhibits HCT116 tumor xenograft in vivo without significant adverse effects, shows stronger anti-cancer efficacy than SAHA.
| M.Wt | 344.385 | |
| Formula | C17H16N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-N-hydroxy-3-(1-(phenylsulfonyl)indolin-5-yl)acrylamide |
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1. Huang HL, et al. PLoS One. 2012;7(8):e43645.
2. Chen MC, et al. Cell Death Dis. 2013 Sep 19;4:e810.
3. Chen CH, et al. Clin Cancer Res. 2014 Mar 1;20(5):1274-1287.
4. Huang HL, et al. Oncotarget. 2015 Mar 10;6(7):4976-91.
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