MPT0L145 | Probechem Biochemicals

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Chemical Structure : MPT0L145

MPT0L145 (MPT0L 145)

Catalog No.: PC-60465Not For Human Use, Lab Use Only.

MPT0L145 is a nove potent, dual FGFR and PIK3C3 inhibitor with Kd of 0.53 nM for PIK3C3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MPT0L145 is a nove potent, dual FGFR and PIK3C3 inhibitor with Kd of 0.53 nM for PIK3C3.
MPT0L145 inhibits FGFR1 and FGFR3 with Kd of 130 nM and 270 nM, respectively.
MPT0L145 persistently increases incomplete autophagy, induces cytoplasmic vacuolization in bladder cancer cells.

Physicochemical Properties

M.Wt	595.91
Formula	C25H29Cl3N8O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-1-methyl-3-(2,4,6-trichloro-3,5-dimethoxyphenyl)urea

References

1. Chen CH, et al. Clin Cancer Res. 2017 Dec 8. pii: clincanres.2066.2017.

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MPT0L145 (MPT0L 145)

Biological Activity

Physicochemical Properties

References

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