Chemical Structure : MPT1B099
CAS No.:
2927489-99-2
MPT1B099
Catalog No.: PC-28157Not For Human Use, Lab Use Only.
MPT1B099 is a potent, dual monoamine oxidase A (MAO-A) and heat shock protein 90 (HSP90) inhibitor with IC50 of 4.58 uM and 16 nM respectively, inhibits growth of both TMZ-sensitive and -resistant GBM cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MPT1B099 is a potent, dual monoamine oxidase A (MAO-A) and heat shock protein 90 (HSP90) inhibitor with IC50 of 4.58 uM and 16 nM respectively, inhibits growth of both TMZ-sensitive and -resistant GBM cells.
MPT1B099 increases HSP70 expression indicating reduced function of HSP90, reduced HER2 and phospho-Akt expression similar to MAO A or HSP90 inhibitor itself.
MPT1B099 decreases IFN-γ induced PD-L1 expression in GL26 cells.
MPT1B099 reduces tumor growth in GL26 mouse model.
MPT1B099 also inhibits the growth of colon cancer, leukemia, non-small cell lung and other cancers.
Physicochemical Properties
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M.Wt
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458.98
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Formula
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C25H31ClN2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-chloro-4-(3-(methyl(prop-2-yn-1-yl)amino)propoxy)phenyl)-N-ethyl-2,4-dihydroxy-5-isopropylbenzamide
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References
1. Tseng HJ, et al. Front Pharmacol. 2026 Aug 24;17:1866411.
2. Tseng H. J., et al. Eur. J. Med. Chem. 256, 115459.
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