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MR837

Chemical Structure : MR837

CAS No.: 1210906-48-1

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MR837 (NSD2-PWWP1 inhibitor 3f, MR 837)

Catalog No.: PC-72292Not For Human Use, Lab Use Only.

MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells.
MR837 (NSD2-PWWP1 inhibitor 3f) decreased the interaction of NSD2-PWWP1 but not NSD3-PWWP1 with histone 3 in cells in a dose-dependent manner with an IC50 of 17.3 uM.

Physicochemical Properties

M.Wt 282.361
Formula C16H14N2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO (2.8 mg/mL)
Chemical Name/SMILES

Benzamide, 4-cyano-N-cyclopropyl-N-(2-thienylmethyl)-

References

1. Renato Ferreira de Freitas, et al. J Med Chem. 2021 Feb 11;64(3):1584-1592.

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