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Chemical Structure : MRL20
Catalog No.: PC-62345Not For Human Use, Lab Use Only.
MRL20 is a novel synthetic PPARγ ligand and orthosteric agonist with canonical LBP binding affinity of 2 nM.
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MRL20 is a novel synthetic PPARγ ligand and orthosteric agonist with canonical LBP binding affinity of 2 nM.
MRL20 can bind to the alternate site of PPARγ covalently bound to an endogenous ligand, increases TRAP220 binding and decreases NCoR binding to 15-oxoETE bound PPARγ with EC50 of 20-30 uM.
| M.Wt | 527.496 | |
| Formula | C28H24F3NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hughes TS, et al. Nat Commun. 2014 Apr 7;5:3571. doi: 10.1038/ncomms4571.
2. Brust R, et al. ACS Chem Biol. 2017 Apr 21;12(4):969-978.
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