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MRS-2365

Chemical Structure : MRS-2365

CAS No.: 436847-09-5

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MRS-2365 (MRS2365)

Catalog No.: PC-61410Not For Human Use, Lab Use Only.

MRS-2365 is a highly potent, selective P2Y1 receptor agonist with EC50 of 1.2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MRS-2365 is a highly potent, selective P2Y1 receptor agonist with EC50 of 1.2 nM.
    MRS-2365 exhibits no agonist activity at the P2Y12 receptor and very low activity at the P2Y13 receptor.
    MRS-2365 induces rapid desensitization of the P2Y1 receptor of human platelets.

    Physicochemical Properties

    M.Wt 549.28
    Formula C13H16N5O9P2SNa3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Diphosphoric acid, mono[[(1R,2R,3S,4R,5S)-4-[6-amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] ester (9CI)

    References

    1. Ravi RG, et al. J Med Chem. 2002 May 9;45(10):2090-100.

    2. Chhatriwala M, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43.

    3. Bourdon DM, et al. J Thromb Haemost. 2006 Apr;4(4):861-8.

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