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Chemical Structure : MRS 1477
Catalog No.: PC-60668Not For Human Use, Lab Use Only.
MRS 1477 is a small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).
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MRS 1477 is a small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).
MRS 1477 increases sensitivity of already sensitized TPRV1 toward capsaicin, does not affect inhibition by capsazepine or ruthenium red and remains effective in potentiating activation by pH in the presence of an orthosteric vanilloid antagonist.
| M.Wt | 389.51 | |
| Formula | C21H27NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kaszas K, et al. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60.
2. Lebovitz EE, et al. Mol Pain. 2012 Sep 21;8:70.
3. Nazıroğlu M, et al. PLoS One. 2017 Jun 22;12(6):e0179950.
4. Roh EJ, et al. Bioorg Med Chem. 2008 Oct 15;16(20):9349-58.
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