MRS 1477 |CAS:212200-21-0 Probechem Biochemicals

Chemical Structure : MRS 1477

MRS 1477 (MRS1477;MRS-1477)

Catalog No.: PC-60668Not For Human Use, Lab Use Only.

MRS 1477 is a small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

MRS 1477 is a small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).
MRS 1477 increases sensitivity of already sensitized TPRV1 toward capsaicin, does not affect inhibition by capsazepine or ruthenium red and remains effective in potentiating activation by pH in the presence of an orthosteric vanilloid antagonist.

Physicochemical Properties

M.Wt	389.51
Formula	C21H27NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,5-diethyl-3-(2-methoxyethylthio)-2-methyl-6-phenyl-1,4-(±)-dihydropyridine-3,5-dicarboxylate

References

1. Kaszas K, et al. J Pharmacol Exp Ther. 2012 Jan;340(1):152-60.

2. Lebovitz EE, et al. Mol Pain. 2012 Sep 21;8:70.

3. Nazıroğlu M, et al. PLoS One. 2017 Jun 22;12(6):e0179950.

4. Roh EJ, et al. Bioorg Med Chem. 2008 Oct 15;16(20):9349-58.

MRS 1477 (MRS1477;MRS-1477)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.