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MRS1523

Chemical Structure : MRS1523

CAS No.: 212329-37-8

MRS1523 (MRS 1523, MRS-1523)

Catalog No.: PC-28428Not For Human Use, Lab Use Only.

MRS1523 (MRS 1523) is a potent and selective adenosine A3 receptor (A3AR) antagonist with Ki of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. 

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Biological Activity

MRS1523 (MRS 1523) is a potent and selective adenosine A3 receptor (A3AR) antagonist with Ki of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. 
MRS1523 shows 140- and 18-fold selectivities over A1 and A2A receptors, respectively.

Physicochemical Properties

M.Wt 399.55
Formula C23H29NO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Propyl 6-ethyl-5-((ethylthio)carbonyl)-2-phenyl-4-propylnicotinate

References

1. Li AH, et al.J Med Chem. 1998 Aug 13;41(17):3186-201.

2. Coppi E, et al. 2019 May;160(5):1103-1118.

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