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Chemical Structure : MRS2179
Catalog No.: PC-61743Not For Human Use, Lab Use Only.
MRS2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM.
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MRS2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM.
MRS2179 displays no appreciable activity at P2Y2, P2Y4, or P2Y6 receptors (>30 uM).
MRS2179 inhibits ADP-induced platelet shape change, aggregation and Ca2+ rise but has no effect on ADP-induced inhibition of adenylyl cyclase.
MRS2179 decreases platelet count in mice.
| M.Wt | 425.2 | |
| Formula | C11H17N5O9P22- | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moro S, et al. J Med Chem. 1998 Apr 23;41(9):1456-66.
2. Baurand A, et al. Eur J Pharmacol. 2001 Feb 2;412(3):213-21.
3. Léon C, et al. Circulation. 2001 Feb 6;103(5):718-23.
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