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MRS2500

Chemical Structure : MRS2500

CAS No.: 779323-43-2

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MRS2500 (MRS-2500)

Catalog No.: PC-61412Not For Human Use, Lab Use Only.

MRS2500 is a highly potent and selective antagonist of the platelet P2Y1 receptor with Ki of 0.78 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MRS2500 is a highly potent and selective antagonist of the platelet P2Y1 receptor with Ki of 0.78 nM.
    MRS2500  inhibits ADP-induced aggregation of human platelets with IC50 of 0.95 nM.
    MRS2500  shows strong antithrombotic activity in mice.

    Physicochemical Properties

    M.Wt 561.166
    Formula C13H18IN5O8P2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2S,4S,5S)-4-(2-iodo-6-(methylamino)-9H-purin-9-yl)-1-((phosphonooxy)methyl)bicyclo[3.1.0]hexan-2-yl dihydrogen phosphate

    References

    1. Kim HS, et al. J Med Chem. 2003 Nov 6;46(23):4974-87.

    2. Hechler B, et al. J Pharmacol Exp Ther. 2006 Feb;316(2):556-63.

    3. Gao ZG, et al. Mol Pharmacol. 2017 Sep 1. pii: mol.117.109660.

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