MRS4833 | P2Y14 inhibitor | Probechem Biochemicals

Chemical Structure : MRS4833

MRS4833 (MRS-4833)

Catalog No.: PC-20962Not For Human Use, Lab Use Only.

MRS4833 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 5.9 nM, Ki of 3.44 nM (human P2Y14R).

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Biological Activity

MRS4833 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 5.9 nM, Ki of 3.44 nM (human P2Y14R).
MRS4833 shows an IC50 of 4.8 nM for mouse P2Y14R.
MRS4833 reduced airway eosinophilia in a protease-mediated asthma model.

Physicochemical Properties

M.Wt	503.52
Formula	C30H24F3NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC(C2=CC=C([C@@]3(O)[C@]4([H])CNC[C@@]3([H])C4)C=C2)=C5C=CC(C6=CC=C(C(F)(F)F)C=C6)=CC5=C1

References

1. Zhiwei Wen, et al. J Med Chem. 2023 Jul 13;66(13):9076-9094.

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MRS4833 (MRS-4833)

Biological Activity

Physicochemical Properties

References

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