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Chemical Structure : MRS4833
Catalog No.: PC-20962Not For Human Use, Lab Use Only.
MRS4833 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 5.9 nM, Ki of 3.44 nM (human P2Y14R).
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MRS4833 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 5.9 nM, Ki of 3.44 nM (human P2Y14R).
MRS4833 shows an IC50 of 4.8 nM for mouse P2Y14R.
MRS4833 reduced airway eosinophilia in a protease-mediated asthma model.
| M.Wt | 503.52 | |
| Formula | C30H24F3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhiwei Wen, et al. J Med Chem. 2023 Jul 13;66(13):9076-9094.
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