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Chemical Structure : MRT-83
CAS No.: 1263131-92-5
Catalog No.: PC-62173Not For Human Use, Lab Use Only.
MRT-83 is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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MRT-83 is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM.
MRT-83 inhibits Bodipy-cyclopamine binding to human and mouse Smo but does not modify Wnt signaling, blocks BC binding to HEK-hSmo cells with IC50 of 4.6 nM.
MRT-83 abrogates the agonist-induced trafficking of endogenous mouse or human Smo, efficiently antagonizes Hh signaling in vivo.
| M.Wt | 538.604 | |
| Formula | C31H30N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide |
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1. Roudaut H, et al. Mol Pharmacol. 2011 Mar;79(3):453-60.
2. Solinas A, et al. J Med Chem. 2012 Feb 23;55(4):1559-71.
3. Lauressergues E, et al. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214.
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