Catalog No.: PC-22495Not For Human Use, Lab Use Only.
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner.
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner.
MS-1020 inhibits STAT signaling in cancer cells with constitutive JAK3 activity, reduces tyrosine phosphorylated STAT3 levels in a dose-dependent manner in L540 cells.
MS-1020 blocks STAT signaling induced by IL-2 in rat T-lymphocyte Nb2 cells.
MS-1020 selectively affects cell viability harboring constitutively-active JAK3, induces apoptosis by down-regulating the expression of anti-apoptotic genes.
