Chemical Structure : MS-1020
CAS No.:
1255516-86-9
MS-1020
(MS1020)
Catalog No.: PC-22495Not For Human Use, Lab Use Only.
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner.
MS-1020 inhibits STAT signaling in cancer cells with constitutive JAK3 activity, reduces tyrosine phosphorylated STAT3 levels in a dose-dependent manner in L540 cells.
MS-1020 blocks STAT signaling induced by IL-2 in rat T-lymphocyte Nb2 cells.
MS-1020 selectively affects cell viability harboring constitutively-active JAK3, induces apoptosis by down-regulating the expression of anti-apoptotic genes.
Physicochemical Properties
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M.Wt
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346.39
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Formula
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C21H18N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide
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References
1. Kim BH, et al. Br J Haematol. 2010 Jan;148(1):132-43.
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