Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MS-1020
Catalog No.: PC-22495Not For Human Use, Lab Use Only.
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner.
MS-1020 inhibits STAT signaling in cancer cells with constitutive JAK3 activity, reduces tyrosine phosphorylated STAT3 levels in a dose-dependent manner in L540 cells.
MS-1020 blocks STAT signaling induced by IL-2 in rat T-lymphocyte Nb2 cells.
MS-1020 selectively affects cell viability harboring constitutively-active JAK3, induces apoptosis by down-regulating the expression of anti-apoptotic genes.
| M.Wt | 346.39 | |
| Formula | C21H18N2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kim BH, et al. Br J Haematol. 2010 Jan;148(1):132-43.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
