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Chemical Structure : MS37452
CAS No.: 423748-02-1
Catalog No.: PC-62651Not For Human Use, Lab Use Only.
MS-37452 is a small-molecule modulator of methyl-lysine binding for CBX7 chromodomain.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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MS37452 is a small-molecule modulator of methyl-lysine binding for CBX7 chromodomain, disrupts CBX7-H3K27me3 and H3K9me3 binding with Ki of 43.0 and 55.3 uM, respectively
MS37452 derepresses transcription of Polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells.
MS37452 disrupts CBX7 binding to the INK4A/ARF locus, subsequently resulting in transcriptional de-repression of its target genes p14/ARF and p16/INK4a in PC3 cells.
| M.Wt | 398.459 | |
| Formula | C22H26N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(2,3-Dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]-piperazine |
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1. Ren C, et al. Chem Biol. 2015 Feb 19;22(2):161-8.
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