MS436 | BRD4 BD1 inhibitor | Probechem Biochemicals

Chemical Structure : MS436

CAS No.: 1395084-25-9

MS436 (MS-436, MS 436)

Catalog No.: PC-21330Not For Human Use, Lab Use Only.

MS436 is a potent, selective BRD4 BD1 bromodomain inhibitor with Ki values of 30-50 nM, 10-fold selectivity over the BD2.

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Biological Activity

MS436 is a potent, selective BRD4 BD1 bromodomain inhibitor with Ki values of 30-50 nM, 10-fold selectivity over the BD2.
MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and pro-inflammatory cytokine interleukin-6 in murine macrophages.

Physicochemical Properties

M.Wt	383.43
Formula	C18H17N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-(pyridin-2-yl)benzenesulfonamide

References

1. Zhang G, et al. J Med Chem. 2013 Nov 27;56(22):9251-64.

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MS436 (MS-436, MS 436)

Biological Activity

Physicochemical Properties

References

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