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Chemical Structure : MS6105
Catalog No.: PC-49594Not For Human Use, Lab Use Only.
MS6105 is the first lactate dehydrogenase (LDH) proteolysis targeting chimera (PROTAC) degrader, degrads both LDHA and LDHB significantly with DC50 of 38 and 74 nM in PANC-1 cells, respectively.
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MS6105 is the first lactate dehydrogenase (LDH) proteolysis targeting chimera (PROTAC) degrader, degrads both LDHA and LDHB significantly with DC50 of 38 and 74 nM in PANC-1 cells, respectively.
MS6105 significantly more potent than the parent LDH inhibitor in suppressing the growth of both quasi-mesenchymal state and epithelial state pancreatic cancer cell lines.
MS6105 is bioavailable in mice through intraperitoneal injection.
| M.Wt | 1228.597 | |
| Formula | C65H81N9O9S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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