Catalog No.: PC-62280Not For Human Use, Lab Use Only.
MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association, completely blocks CBP BRD/p53-AcK382 interactions at 50 uM, results in loss of p53 phosphorylation at Ser15 as well as acetylation at Lys382.
MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association, completely blocks CBP BRD/p53-AcK382 interactions at 50 uM, results in loss of p53 phosphorylation at Ser15 as well as acetylation at Lys382.
MS7972 causes a dramatic decrease of the doxorubicin-induced p53 increase in U2OS cells.
Physicochemical Properties
M.Wt
227.263
Formula
C14H13NO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
9-Acetyl-3,4-dihydro-2H-carbazol-1-one
References
1. Sachchidanand, et al. Chem Biol. 2006 Jan;13(1):81-90.
