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Chemical Structure : MSC-1186
CAS No.: 2871698-23-4
Catalog No.: PC-49773Not For Human Use, Lab Use Only.
MSC-1186 (MSC2711186) is a potent, highly selective pan-SRPK inhibitor with I50 of 2.7 nM, 81 nM and 0.6 nM against SRPK1, SRPK2 and SRPK3, respectively.
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|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
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| 100 mg | Get quote |
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MSC-1186 (MSC2711186) is a potent, highly selective pan-SRPK inhibitor with I50 of 2.7 nM, 81 nM and 0.6 nM against SRPK1, SRPK2 and SRPK3, respectively.
MSC-1186 exhibits highly potent cellular activity for SRPK1 and SRPK3 in HEK293T cells with EC50 values of 98 nM and 40 nM, respectively.
MSC-1186 displays excellent kinome-wide selectivity.
The combination of MSC-1186 with CDC2-like kinase (CLK) inhibitors showed additive attenuation of SR-protein phosphorylation compared to the single agents.
| M.Wt | 461.90 | |
| Formula | C19H17ClFN7O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-(((2-(5-chloro-4-fluoro-1H-benzo[d]imidazol-2-yl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide |
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1. Martin Schröder, et al. J Med Chem. 2023 Jan 12;66(1):837-854.
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