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You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-MSI-1436
MSI-1436

Chemical Structure : MSI-1436

CAS No.: 186139-09-3

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MSI-1436 (Trodusquemine;Aminosterol-1436;MSI1436)

Catalog No.: PC-42921Not For Human Use, Lab Use Only.

MSI-1436 (Trodusquemine) is an non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B 1-405.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MSI-1436 (Trodusquemine) is an non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B 1-405.
MSI-1436 antagonizes HER2 signaling, inhibits tumorigenesis in xenografts and abrogates metastasis in the NDL2 mouse model of breast cancer.

Physicochemical Properties

M.Wt 685.0564
Formula C37H72N4O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

Cholestane-7,24-diol, 3-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-

References

1. Krishnan N, et al. Nat Chem Biol. 2014 Jul;10(7):558-66.

2. Qin Z, et al. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.

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