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Chemical Structure : MSX-122
CAS No.: 897657-95-3
Catalog No.: PC-38724Not For Human Use, Lab Use Only.
MSX-122 is a small molecule and partial CXCR4 antagonist, directly binds to the CXCL12 site on CXCR4 and inhibits CXCR4/CXCL12 actions with IC50 of 10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $398 | In stock | |
| 1 g | Get quote |
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MSX-122 is a small molecule and partial CXCR4 antagonist, directly binds to the CXCL12 site on CXCR4 and inhibits CXCR4/CXCL12 actions with IC50 of 10 nM.
MSX-122 (100 nM) effectively blocked invasion of 78% MDA-MB-231 cells while the same concentration of AMD3100 blocked invasion of 62% cells.
MSX-122 exhibits a different profile than AMD3100 and other reported anti-CXCR4 compounds: (1) MSX-122 did not inhibit T-tropic HIV infection (via the formation of the CXCR4/CD4/GP120 complex), while AMD3100; (2) unlike AMD3100, MSX-122 proved to be inactive in our calcium flux assay.
MSX-122 attenuates colonic damage in mice with experimental colitis, inhibits inflammation induced by carrageenan and lung fibrosis induced by bleomycin.
MSX-122 blocks metastasis in an experimental animal model of breast cancer metastasis, also inhibit metastatic progression in an orthotopic mouse model of uveal melanoma micrometastasis.
| M.Wt | 292.346 | |
| Formula | C16H16N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N,N'-(1,4-phenylenebis(methylene))dipyrimidin-2-amine |
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1. Liang Z, et al. PLoS One. 2012;7(4):e34038.
2. Shu HK, et al. PLoS One. 2013 Nov 7;8(11):e79768.
3. Wu X, et al. Cancer Sci. 2022 Mar;113(3):926-939.
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