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Chemical Structure : MT16-001
Catalog No.: PC-72699Not For Human Use, Lab Use Only.
MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).
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MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM).
MT16-001 inhibits structurally unrelated DUB USP30 with similar potency.
MT16-001 showed cytotoxicity in human embryonic kidney cells (HEK293) with EC50 of 730 nM, effectively engaged UCHL1 in cells with EC50 of 550 nM.
MT16-001 showed excellent selectivity for UCHL1 across the UCH family: UCHL1, UCHL3, UCHL5 and BAP1.
| M.Wt | 298.364 | |
| Formula | C15H14N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943.
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