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Chemical Structure : MT16-205
Catalog No.: PC-72221Not For Human Use, Lab Use Only.
MT16-205 (MT 16-205) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 600 nM, no inhibition agianst UCHL3 (IC50>10 uM).
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MT16-205 (MT 16-205) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 600 nM, no inhibition agianst UCHL3 (IC50>10 uM).
MT16-205 inhibited both UCHL1 and the structurally unrelated DUB USP30 with similar potency.
MT16-205 displayed cell proliferation cytotoxicity in human embryonic kidney cells (HEK293) with IC50 of 350 nM, MT16-205 effectively engaged UCHL1 in cells with IC50 of 830 nM.
| M.Wt | 322.386 | |
| Formula | C17H14N4OS | |
| Appearance | Solid | |
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1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943.
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