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MTB-9655

Chemical Structure : MTB-9655

CAS No.: 2332820-04-7

MTB-9655 (MTB9655)

Catalog No.: PC-23738Not For Human Use, Lab Use Only.

MTB-9655 is a potent, selective and orally bioavailable Acetyl-Coenzyme A Synthetase 2 (ACSS2) inhibitor with biochemical IC50 of 0.15 nM and EC50 of 3 nM in cellular assays.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $348 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MTB-9655 is a potent, selective and orally bioavailable Acetyl-Coenzyme A Synthetase 2 (ACSS2) inhibitor with biochemical IC50 of 0.15 nM and EC50 of 3 nM in cellular assays.
MTB-9655 induces anti-tumor effects in xenograft mouse models of human colorectal, breast and lung cancers that express high levels of ACSS2.

Physicochemical Properties

M.Wt 415.40
Formula C21H19F2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzoic acid, 3-[4-[[[3-(1,1-difluoroethyl)phenyl]amino]carbonyl]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-, methyl ester

References

1. Ruth Perets, et al. Journal of Clinical Oncology Volume 40, Number 16_suppl, 2022 ASCO Annual Meeting I

2. Andreas Goutopoulos, et al.Cancer Res (2022) 82 (12_Supplement): 2326.

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