MTDH-SND1 PPI inhibitor C19

Chemical Structure : MTDH-SND1 PPI inhibitor C19

Catalog No.: PC-23758Not For Human Use, Lab Use Only.

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Biological Activity

MTDH-SND1 PPI inhibitor C19 is a small-molecule inhibitor of MTDH-SND1 PPI with IC50 of 487 nM, directly binds to the SND1-purified protein, degrades SND1 and downregulates downstream at the protein level.
C19 inhibits breast cancer cell proliferation (MCF-7 cells, IC50=626 nM) and invasion/migration, arrested cell cycle, and induced cell apoptosis.
C19 demonstrated promising inhibitory efficacy for tumor growth in xenograft models

Physicochemical Properties

M.Wt	353.37
Formula	C18H12FN3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-Fluoroquinolin-8-yl)quinoline-8-sulfonamide

References

1. Shen H, et al. J Med Chem. 2025 Jan 10. doi: 10.1021/acs.jmedchem.4c02574.

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