MWAC-3634 | EBOV glycoprotein inhibitor

Chemical Structure : MWAC-3634

MWAC-3634 (MWAC3634)

Catalog No.: PC-28410Not For Human Use, Lab Use Only.

MWAC-3634 is a potent small-molecule inhibitor targeting Ebola virus (EBOV) glycoprotein (GP), binds GP with high affinity (Kd=40.7 nM), potently neutralizes infection (IC50= 0.65 nM), inhibits EBOV entry through glycoprotein stabilization.

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Biological Activity

Physicochemical Properties

M.Wt	732.20
Formula	C42H33ClF3N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4R)-1-(2-(6-chloroquinolin-4-yl)-1-((R)-1-(naphthalen-1-yl)ethyl)-1H-benzo[d]imidazole-6-carbonyl)-N-methyl-4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide

References

1. Bu F, et al. Nat Commun. 2026 Sep 1;17(1):10401.

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MWAC-3634 (MWAC3634)

Biological Activity

Physicochemical Properties

References

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