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Chemical Structure : MYC inhibitor EN4
CAS No.: 1197824-15-9
Catalog No.: PC-73141Not For Human Use, Lab Use Only.
MYC inhibitor EN4 is a covalent ligand and inhibitor of MYC, targets cysteine 171 of MYC and inhibits MYC transcriptional activity (EC50=2.8 uM).
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| 50 mg | $328 | In stock | |
| 100 mg | $588 | In stock | |
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MYC inhibitor EN4 is a covalent ligand and inhibitor of MYC, targets cysteine 171 of MYC and inhibits MYC transcriptional activity (EC50=2.8 uM).
EN4 inhibited MYC/MAX binding to the E-box response element DNA consensus sequence in a dose-responsive manner with EC50 of 6.7 uM.
EN4 directly and covalently modifies pure full-length c-MYC protein at C171 to inhibit MYC/MAX DNA binding in vitro.
EN4 engages MYC in cells, reduced MYC and MAX thermal stability in 231MFP breast cancer cells.
EN4 downregulates multiple MYC transcriptional targets, and impairs tumorigenesis.
| M.Wt | 416.477 | |
| Formula | C25H24N2O4 | |
| Appearance | Solid | |
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1. Lydia Boike, et al. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17.
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