Chemical Structure : MZ-101
CAS No.:
2839908-40-4
MZ-101
(MZ101)
Catalog No.: PC-21680Not For Human Use, Lab Use Only.
MZ-101 is a potent, selective inhibitor of glycogen synthase 1 (GYS1) with IC50 of 41 nM (human GYS1), with no inhibition against GYS2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MZ-101 is a potent, selective inhibitor of glycogen synthase 1 (GYS1) with IC50 of 41 nM (human GYS1), with no inhibition against GYS2.
MZ-101 shows similar potency and selectivity of MZ-101 for the mouse isoform of GYS1.
MZ-101 potently and selectively inhibits GYS1 by a noncompetitive mechanism.
MZ-101 reduces glycogen abundance in a dose-dependent manner in fibroblasts from healthy controls and patients with Pompe disease with a mean EC50 of 500 nM.
MZ-101 inhibits glycogen synthesis across species and cell types expressing GYS1, independent of defects in glycogen catabolism.
MZ-101 inhibits GYS1 but not GYS2 de novo glycogen synthesis in WT and Pompe mice.
Physicochemical Properties
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M.Wt
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449.53
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Formula
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C25H28FN5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R)-1-(2-(1H-1,2,3-triazol-5-yl)acetyl)-4-fluoro-N-((S)-(4-isopropylphenyl)(phenyl)methyl)pyrrolidine-2-carboxamide
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References
1. Ullman JC, et al. Sci Transl Med. 2024 Jan 17;16(730):eadf1691.
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