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Chemical Structure : Mapracorat
CAS No.: 887375-26-0
Catalog No.: PC-61603Not For Human Use, Lab Use Only.
Mapracorat (ZK 245186) is a potent, selective and non-steroid glucocorticoid receptor (GR) agonist with binding Ki of 1.9 nM.
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Mapracorat (ZK 245186) is a potent, selective and non-steroid glucocorticoid receptor (GR) agonist with binding Ki of 1.9 nM.
Mapracorat (ZK 245186) does not show significant activity for ERα, PR, AR or MR.
Mapracorat (ZK 245186) shows anti-inflammatory efficacy after topical application similar to the classical glucocorticoids, with a better safety profile.
| M.Wt | 462.489 | |
| Formula | C25H26F4N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol |
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1. Schäcke H, et al. Br J Pharmacol. 2009 Oct;158(4):1088-103.
2. Zhang JZ, et al. Mol Vis. 2009 Dec 8;15:2606-16.
3. Shafiee A, et al. Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1422-30.
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